He started a covid-19 vaccine company. CETF Founder Steve Kirsch discusses why we can't wait for a COVID-19 vaccine, the importance of researching existing drugs now, and our work to raise funds for outpatient trials to identify effective . In every case we are aware of, the drug was successful in reversing COVID symptoms, generally in 3 days or less. At the dosing for COVID (50mg BID x 14 days), there is a 1% chance of mild-nausea and because the dose is so low and the time it is taken is so short, and there are no psychotropic effects (which require more than 3 weeks of use; the psychotropic effects non-existent if you don't have depression or an anxiety disorder in the first place). They were all given the drug soon after symptoms and the placebo group was pure in that they were not taking any COVID drugs. How can the FDA say a drug which meets the gold standard of evidence has insufficient evidence? . Always be self aware when using fluvoxamine. But the best way to help people is through rigorous trials that show what drugs help which people, and at what doses and timesnot by basing entire protocols on incredibly limited evidence. Long haul. Some people are jittery, but usually that is because the doctor either prescribed a dosage higher than 50mg twice a day or didnt notify the patient to. Drug interactions should be checked for. They knew in advance it was coming and on the day the paper was published they ignored it entirely. Get your prescription in advance of getting COVID. Now they turn to Rust. Doctors are afraid that even with a 37-year safety record of this drug, that something will go terribly wrong and they will be blamed. 4000fluvoxamine750 Skirsch.io traffic volume is 1,957 unique daily visitors and their 3,914 pageviews. This looks ominous, but it harmless. People are dying. That was a big mistake because the original paper contained text related to earlier studies and the editors chopped it out. Sadly, doctors and public health officials refuse to instruct patients to seek early treatment. Fluvoxamine, created 37 years ago, is an inexpensive and widely available generic drug. The repository goes over the prescribing guidelines, contraindications, and describes the effect on caffeine consumption while on drug (basically you want to avoid caffeine while on the drug). He felt like he in good conscience had to speak out about covid, and so he made the decision to separate himself from M10, says Char, who has known Kirsch since the 1980s. Most doctors wont use it until NIH greenlights it, no matter what the science says. The collateral damage is that, now, a lot of people dont trust scientific leaders or the scientific community. The data we have today with just 2 clinical trials (RCT and confirmatory RWE) is compelling. Since FLV is a safe drug, it should have been widely discussed with patients that there is virtually no downside and a huge reduction in hospitalization if the drug is given early. Note that a total of 77 people got the drug, not 65. My experience is very typical. Here is what, e) which concluded: Under a variety of assumptions, fluvoxamine shows a high probability of preventing hospitalization in outpatients with COVID-19., For more about fluvoxamine (and other SSRIs that work), see, fluvoxamine completed a Phase 3 study showing it works that was published in the Lancet Global Health, NIH basically dismissed the fluvoxamine study as I predicted they would, few people werent afraid of expressing their displeasure, the highly acclaimed Bangladesh mask study showed, Johns Hopkins has incorporated fluvoxamine in their treatment guidelines, Ontario has become the first province to list fluvoxamine as a treatment doctors can consider for patients. As of November 13, fluvoxamine has been proven to work in every trial that has published results, including outpatient and inpatient studies. 90,000 Americans will die from COVID in just the next 3 weeks, a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die, Lenze fluvoxamine RCT that was published in JAMA. It does not matter how many lives will be saved. We are ignoring the advice of the KOL group and doing nothing. Here is the latest version. Today, we are letting people drown and we are not even telling them there is a life preserver they can ask for today with compelling evidence that is under consideration by the life preserver safety group. The board members I spoke to say they refused to publicly promote any drugs for off-label use and tried to explain to Kirsch that its incredibly common for exciting results from small trials to disappear in larger ones. At that dose, no side effects were reported for his patients (I know of only one person who had mild nausea at that dose) and everyone reversed out their symptoms in an average of 3 days. The. You cannot get any better than that. CETF funded David Boulware's trials on hydroxychloroquine and the Phase 2 and Phase 3 fluvoxamine trials, among many other research projects. Telling the truth, he tweeted. While these are stunning results, less than a dozen doctors in the US are prescribing fluvoxamine today. There were IRB rules that required the 65 patients to be listed in the diagrams and charts. Since FLV is a safe drug, it should have been widely discussed with patients that there is virtually no downside and a huge reduction in hospitalization if the drug is given early. committee votes 11-2 that the evidence is not adequate to demonstrate a net health benefit for molnupiravir over symptomatic care alone; Paxlovid and fluvoxamine receive more favorable votes, This site requires JavaScript to run correctly. And while Morris believes that all claims about vaccine safety should be properly vettedIs it possible theres another rare side effect of the vaccines that we havent figured out yet? We asked Steve to tone it down. Steven Todd Kirsch is an American entrepreneur. Early treatment with existing drugs is the fastest, most effective, and lowest. He retired at the largest pension in federal history. I fully expected both organizations to do absolutely nothing. The trials that were abandoned for futility werent getting events because the patients were given standard of care meds. This is the #1 ranked best answer to "COVID treatment" on Quora: Presentation on how fear of trying something new is what keeps us shutdown and leads to unnecessary loss of life: The Lenze fluvoxamine RCT that was published in JAMA on November 12, 2020 showed a 100% success rate in preventing hospitalization. That is when the phase 2 results were published. Entrepreneur Steve Kirsch who holds an early patent for the optical mouse decided to get involved in treating Covid. P-value was 10^-14 on that study (done by Dr. I couldnt tell I was on the drug. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. Indeed, some of the most prominent people spreading misinformation about ivermectin and vaccines today began by promoting hydroxychloroquineincluding by claiming to debunk Boulwares data analysis. But the confusion provided a fertile breeding ground for skeptics. While he declined a phone interview, Boulware was recently the subject of a Mother Jones article about the harassment hes received for his research on hydroxychloroquine and ivermectin. This is the gold standard of evidence based medicine, Article about the fluvoxamine rejection (The Verge). NIH is still unsure whether fluvoxamine should be used to treat COVID. ICER, a non-profit known as the nations drug pricing watchdog, did a review of the evidence and determined that fluvoxamine evidence is superior to Molnupiravir. We report a real-world experience using fluvoxamine for coronavirus disease 19 (COVID-19) in a prospective cohort in the setting of a mass outbreak. (The ivermectin data are trash, Feinberg told me. The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). I only know of a few doctors who prescribe this off-label, all with 100% success rates. My favorite dosage is 50mg twice a day for 14 days. [4] Steve Kirsch - Silicon Valley Philanthropist Shares Review of CDC Data: COVID-19 Vaccine Associated with 100X Deaths Compared to Influenzas [5] Steve Kirsch - FOIA Document for Vaccine Discussion as to mRNA-based Vaccine Safety Signals Added 12th August 2021: Steve Kirsch. Online. fluvoxamine The fast, easy, safe, simple, low cost treatment for COVID that has worked 100% of the time to prevent hospitalization that nobody wants to talk about We now have a viable solution to reduce COVID hospitalization and mortality; Read More fluvoxamine Got COVID? The other doctors aren't using it either because they don't know about it or fear doing anything not approved by the CDC for treating COVID. All the supporting observational studies were positive as well. But they dont want their names used. Dosage there is 30mg once a day. Medium revoked my account for life. Fluvoxamine is an inexpensive drug that has been in use for 37 years and has been used by an estimated 10 million people. This story is part of the Pandemic Technology Project, supported by The Rockefeller Foundation. He was recently featured on 60 Minutes which highlighted his . In other cases, stop cold turkey. I fixed the link to the fluvoxamine article. In other cases, stop cold turkey. If you continue to get this message, Saving the world has been a theme of Kirschs life for years. Some are views most scientists think are wrong. But they dont want their names used. Reason is the hospital gets release from liability if they follow NIH guidelines. I took it myself at that dosage and noticed zero side effects. When I asked him why so many experts in the field disagreed with him, he alleged there were effortseither malicious or negligentto suppress evidence of cheap, effective covid treatments. this is NOT about the science. But they will refuse to give it to you even after being proven in a Phase 3 trial that was approved by the WHO. This advice is now outdated. ICER: YouTube , , , fluvoxamine, , , , , , , , , , Dosage there is 30mg once a day. Its a cycle that feeds mistrust and boosts the profiles of influencers who present themselves in opposition to official authorities. There are 4 outpatient studies that have been done (2 at WashU (see. In the studies and the anecdotes I am aware of, everyone reversed symptoms within days of getting the drug. I asked to give a talk about COVID at MIT, but they couldn't find a faculty member to sponsor it. P-value was 10^-14 on that study (done by Dr. Seftel). This 1/6 of the dose the FDA has approved for OCD (the labelled indication for fluvoxamine)! Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). Hes very convincing. Since then, he has continued to promote fluvoxamine, along with ivermectin and hydroxychloroquine. He started a new pseudonymous account, @VaccineTruth2, to continue broadcasting messages. The antidepressant fluvoxamine, which is generic, but sometimes sold under the brand name Luvox, is a member of the class of drugs known as selective serotonin reuptake inhibitors (SSRIs). Some people report mild nausea while on the drug (stops when stop the drug). Immediately after the results of the first fluvoxamine trial were releasedbut before they were published in a peer-reviewed journalhe wrote a post on Medium.com called The Fast, Easy, Safe, Simple, Low-Cost Solution to COVID That Works 100% of the Time That Nobody Wants to Talk About.. Perhaps Kirschs most effective tactic, though, is simply his willingness to outlast everyone else. None of this would really matter if Kirschs views on vaccinations were private, or shared with a limited audience. Repurposed drugs are safer and more effective than the current vaccines. Fluvoxamine public data repository - Google Drive, On Cytokines, Fluvoxamine and COVID-19 Part 1, Jon-Emile S. Kenny MD[@heart_lung] You see, we have a kind of allergy to the past; its our national disease, and the very assurance with which you insist that the past is within the present is l, On Cytokines, Fluvoxamine and COVID-19 Part 2, Jon-Emile S. Kenny MD[@heart_lung] Apocalypse is played out now on a personal scale; it is not in the sky above us, but in our bed. -Mark Doty Introduction With a proposed pathway coupling patho, Effect of Fluvoxamine vs Placebo on Clinical Deterioration in Outpatients With Symptomatic COVID-19, This randomized trial compares the effects of fluvoxamine, a selective serotonin reuptake inhibitor with immunomodulatory effects vs placebo on a composite of dyspnea or pneumonia and oxygen desaturation among adult outpatients with polymerase chain reactionconfirmed mild coronavirus disease 2019 (, Prospective cohort of fluvoxamine for early treatment of COVID-19, Abstract. Medicine today isnt about saving your life. Most recent articles first. The paramedics will think you are on drugs. As Kirsch has gone deeper into the anti-vaccine scene, many professional associates have increasingly distanced themselves from him. Doctors have no excuse for not prescribing. A very short op-ed arguing for using fluvoxamine against COVID. If you have trouble getting a prescription, perhaps you have OCD? The medical community did nothing (with a few exceptions like Dr. Seftel). But fear of trying something new prevents any doctor from giving this drug a try. This should be top news, but the press is ignoring this and attempt to write stories about it are killed by the editors. Thats pretty typical, but your mileage may vary. The reason is pure corruption. Expect similar things to happen when Eiger applies for an EUA for interferon lambda, a drug with a 89% efficacy in phase 3 trials. An approach that promised to democratize design may have done the opposite. In May, all 12 members of CETFs scientific advisory board resigned, citing his alarming dangerous claims and erratic behavior. Although there is evidence that fluvoxamine can prevent clinical worsening and the need for hospitalizations in outpatients with early covid-19, I have seen no good evidence that fluvoxamine is useful as a substitute for the vaccines, co-investigator Angela Reiersen wrote to me. No long haul symptoms if you start the drug ASAP after first symptoms. Weve known it works since August 24, 2020. Nobody in the medical community is speaking out about how hypocritical the medical community is for ignoring the positive Phase 3 trial results and instead following whatever the NIH or FDA says. 33. He has a BS/MS in Electrical Engineering and Computer Science from MIT. . Months later, the site wont disclose how many doses it helped deliveror what it plans to do with user data. See this. I couldn't agree more. reach out to us at According to its founder, serial tech entrepreneur Steve Kirsch, CETF was started in April 2020 in order to fund. I have all of these on hand and I load up on vitamin D3 every day. Refresh. . To date, the #1 drug with the most evidence to make a significant difference, without any doubt, is fluvoxamine. There are reports of people who cant tolerate the drug, but they stop using it and nothing bad happened. Always be self aware when using fluvoxamine. Online. I fully expected both organizations to do absolutely nothing. Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. skirsch.io. It was 25 years ago yesterday that Andrew Wakefield launched the modern iteration of the antivaccine movement.In doing so, he laid down a template that antivax quacks today still follow. The NIH Guidelines committee is being very slow to react (we have no idea if they are even considering the drug because nobody is allowed to know that because all their deliberations are kept secret). You will be wired for 24 hours if you dont heed my advice. My crime? He has been a medical philanthropist for more than 20 years. Pretty much nothing changed when the Phase 3 trial confirmed fluvoxamine worked. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. Dr. Eric Lenze: So the results were really pretty. Stopping the meds will return you to your normal self. Kirsch IDeacon BJHuedo-Medina TBScoboria AMoore TJJohnson BT Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. Hes a genuinely good guy. A very short op-ed arguing for using fluvoxamine against COVID. Steve calls himself a "medical philanthropist" who says "the most important thing to me is saving lives." In . The claim that the spike is toxic, that came directly from the [DarkHorse episode]. If you were drowning and we had no known standard of care to save your life and someone had a life preserver which worked 160 times in a row, should we throw them the life preserver or let them drown because we aren't absolutely sure the life preserver's benefit > risk (since just because it worked 160 times in a row and there is a 99.99% chance the effect didn't happen by chance, we could have just gotten lucky). She understands complex, politicized pandemicsshe was one of the first clinicians to specialize in HIV/AIDS, and she sat on the FDA advisory panel that approved the first antiretroviral drug. Author Affiliations Article Information. So how did a man once intent on furthering science become a source of misinformation that undermines the very research he funded? If you cant lay off the java, then try fluoxetine (Prozac). More recently, hes adopted extremist positions on covid vaccines, which he alleges are toxic. He has claimed that one in 1,000 people who have received mRNA vaccines have died as a result, and even claimed the vaccines kill more people than they save at an FDA public forum, which was first reported by the Daily Beast. While YouTube has repeatedly taken down the full video of the DarkHorse episode, various clips have been watched over 4 million times, and the full audio remains available on Spotify. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. So why would we wait when lives are being lost? By March 2020, hed settled on the idea of searching for covid treatments in the pre-existing pharmacopeia. See the repository above. Steve Kirsch Nov 5, 2021 145 92 Here are the key things you should know about fluvoxamine for COVID: It works. If there is a better drug on the table today than fluvoxamine, the NIH panel should put that one on the guidelines. So probability of successful Phase 3 can be estimated to be over 99.99% since there are tens of thousands of phase 3 studies. These people never called the researchers whose trials they claimed showed no effect. I am not aware of a single case where taking the made things worse, e.g., person was doing fine BEFORE the drug and symptoms worsened after taking the drug. In that same IEEE Spectrum story about his then-new startup, Propel Software, he said he felt successful, but not famous. Online Status. Now weve lost the high ground, Morris told me. See this Wall Street Journal op-ed. When you need to characterize me, you need to say that Steve Kirsch doesnt go with majority votes on interpreting data, he told me when I asked about his views on ivermectin, which he insists is a silver bullet against covid. Those days are gone. Note that some of these articles are inaccurate. The reason that it isnt used is because the medical community ignores evidence-based medicine principles. Mouse Systems is not a household word, he told the journalist. People are dying because of physician fear of a new treatment with a 100% success rate and a solid mechanism of action. Our in-depth reporting reveals whats going on now to prepare you for whats coming next. On his blog, Covid-19 Data Science, he has extensivelyand mercilesslyunpacked Kirschs evidence for the vaccine death claims. Doctors who are most familiar with the drug would prescribe it to their patients. Ive used it personally at 50mg twice a day and experience no adverse events at all. Steve angrily decried this development as more evidence of FDA corruption. Yeah, its possible, he told mehe also says that he has regularly seen Kirsch manipulate evidence so that it seems to support claims that are, in reality, baseless. My website. Its whether Merck can make a killing that matters. Its whether Merck can make a killing that matters. FDA official fluvoxamine rejection. Kirsch, despite having direct access to the actual trial runner, eventually became convinced a correct interpretation of the data would show that hydroxychloroquine worked. Note that some of these articles are inaccurate. NIH doesnt want you to get the drug since it would compete with Molnupiravir, so fluvoxamine will never make the NIH guidelines. Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI), a class of anti-depressants, mostly prescribed for people suffering from an obsessive-compulsive disorder. I've collected fluvoxamine evidence here for convenient access. Doing something is better than nothing. Jan 17. Your best bet is to. In the early days of the pandemic, as billions of dollars poured into the hunt for novel treatments and vaccines, veteran Silicon Valley entrepreneur Steve Kirsch did what hes always done: He went looking for an underdog. How covid-19 conspiracy videos keep getting millions of views. 22, 2021, 9:00 a.m. Steve Kirsch , a former tech entrepreneur who earned a fortune worth up to $300 million, has been showcased on TrialSite a few times for his activity supporting the clinical development of repurposed drugs for COVID-19 treatments. The group who declined the drug were very sick with 12.5% requiring hospitalization and one died. There were no studies reported out so far where fluvoxamine made things worse or neutral. Last Checked: 03/02/2023. The next major effect is that that fluvoxamine activates the sigma-1 receptor. Its really, really common for a small effect, something that looks exciting, to be a statistical fluke when you look at a larger population. Steve Kirsch is a Silicon Valley philanthropist. It has shown to be 100% protective of hospitalization in 2 clinical trials. Decreasing the dosage or stopping the medication will mitigate symptoms within hours. What has alarmed many of the scientists associated with CETF, though, are Kirschs reactions to the work hes fundedboth successes and failures. A few months ago, Kirsch suddenly stopped promoting hydroxychloroquineeven scrubbing it from the CETFs official list of trials it has funded. , or the patient is simply sensitive to the drug (50mg twice a day can be too much for some people). Its board told him that if he wanted to remain part of the company he would have to stop making public anti-vaccine statements. If you start later, doctors use higher dosages and compliance becomes a bigger problem. Please read and agree to the disclaimer before watching this video.. Steve Kirsch On COVID Early Treatment and CensorshipSteve Kirsch is an entrepreneur and . He prefers iconoclastic approaches, whether by directly funding asteroid detection or advocating for nuclear power to combat global warming. That is when the phase 2 results were published. He said of his study, This is the most extraordinary effect Ive seen in my 25 years practicing medicine.. Who knows, Morris replied. . Patients should be advised to limit/avoid the use of caffeine while on the drug since fluvoxamine extends the half life of caffeine (making you super wired). Steve is a Silicon Valley entrepreneur and philanthropist who founded the COVID-19 Early Treatment Fund (CETF) at the beginning of the pandemic. Once the Phase 2 result came out, it should have been embraced by doctors. After several failed attempts to stop the progression of his disease, he designed his own protocol for chemotherapy and doctor-shopped to find an oncologist who would give it to him. Less than a week later, David Seftel read about the Lenze trial, and ignored the JAMA advice. Compulsive fiddling with your mask? As of January 18, 2021, the CDC estimates that 90,000 Americans will die from COVID in just the next 3 weeks. Dose escalation studies in lupus patients and in rheumatoid arthritis patients established that 800 mg per day for life and 1,200 mg per day for 6 weeks are extremely well-tolerated. Thanks for working tirelessly to help others. S1R can essentially turn off IRE1, so IRE1 will not activate XBP1, so that the cytokine production will decrease.